| Pair Name | Saikosaponin D, 1,9-Pyrazoloanthrone | ||
| Phytochemical Name | Saikosaponin D (PubChem CID: 107793 ) | ||
| Anticancer drug Name | 1,9-Pyrazoloanthrone (PubChem CID: 8515 ) | ||
| Structure of Phytochemical |
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2D
MOL
3D
MOL
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| Structure of Anticancer Drug |
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2D
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3D
MOL
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| Pair Name | Saikosaponin D, 1,9-Pyrazoloanthrone | |||
| Disease Info | [ICD-11: 2B51] | Osteosarcoma | Investigative | |
| Biological Phenomena | Induction-->Mitochondria-mediated apoptosis | |||
| Gene Regulation | Down-regulation | Phosphorylation | AKT1 | hsa207 |
| Up-regulation | Expression | BAX | hsa581 | |
| Down-regulation | Expression | BCL2 | hsa596 | |
| Up-regulation | Expression | CASP3 | hsa836 | |
| In Vitro Model | U2OS | Osteosarcoma | Homo sapiens (Human) | CVCL_0042 |
| Result | A dramatic inhibition of cellular proliferation, invasion, and migration in cells treated with Ssd alone or in combination with SP600125 was observed | |||
| No. | Title | Href |
|---|---|---|
| 1 | Use of Saikosaponin D and JNK inhibitor SP600125, alone or in combination, inhibits malignant properties of human osteosarcoma U2 cells. Am J Transl Res. 2019 Apr 15;11(4):2070-2080. | Click |
